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Journal article

Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons.

Abstract:

The microtubule-associated protein tau (MAPT) and alpha-synuclein (SNCA) genes play central roles in neurodegenerative disorders. Mutations in each gene cause familial disease, whereas common genetic variation at both loci contributes to susceptibility to sporadic neurodegenerative disease. Here, we demonstrate exquisite gene regulation of the human MAPT and SNCA transgene loci and functional complementation in neuronal cell cultures and organotypic brain slices using the herpes simplex virus...

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Publication status:
Published

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Publisher copy:
10.1038/mt.2009.64

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Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
17
Issue:
9
Pages:
1517-1526
Publication date:
2009-09-01
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Source identifiers:
113384
Language:
English
Keywords:
Pubs id:
pubs:113384
UUID:
uuid:cfa47df5-8875-48e8-9a8f-27afc148bacf
Local pid:
pubs:113384
Deposit date:
2012-12-19

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