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Journal article

Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons.

Abstract:

The microtubule-associated protein tau (MAPT) and alpha-synuclein (SNCA) genes play central roles in neurodegenerative disorders. Mutations in each gene cause familial disease, whereas common genetic variation at both loci contributes to susceptibility to sporadic neurodegenerative disease. Here, we demonstrate exquisite gene regulation of the human MAPT and SNCA transgene loci and functional complementation in neuronal cell cultures and organotypic brain slices using the herpes simplex virus...

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Publication status:
Published

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Publisher copy:
10.1038/mt.2009.64

Authors


Peruzzi, PP More by this author
Lawler, SE More by this author
Senior, SL More by this author
Dmitrieva, N More by this author
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Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
17
Issue:
9
Pages:
1517-1526
Publication date:
2009-09-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:cfa47df5-8875-48e8-9a8f-27afc148bacf
Source identifiers:
113384
Local pid:
pubs:113384

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