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Journal article

Blood pressure and cerebral white matter share common genetic factors in Mexican Americans

Abstract:

Elevated arterial pulse pressure and blood pressure (BP) can lead to atrophy of cerebral white matter (WM), potentially attributable to shared genetic factors. We calculated the magnitude of shared genetic variance between BP and fractional anisotropy of water diffusion, a sensitive measurement of WM integrity in a well-characterized population of Mexican Americans. The patterns of whole-brain and regional genetic overlap between BP and fractional anisotropy were interpreted in the context th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Kochunov, P More by this author
Lancaster, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Karlsgodt, K More by this author
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Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
57
Issue:
2
Pages:
330-335
Publication date:
2011-02-01
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
URN:
uuid:cfa342b3-7cb8-492b-8bc2-13835388c733
Source identifiers:
445994
Local pid:
pubs:445994

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