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Pharmacokinetics of orally administered oseltamivir in healthy obese and nonobese thai subjects

Abstract:

Oseltamivir is the most widely used anti-influenza drug. In the 2009 H1N1 pandemic, in which the influenza viruses were oseltamivir sensitive, obesity was identified as a risk factor for severe disease and unfavorable outcomes. The aim of this study was to investigate the pharmacokinetic properties of oseltamivir and its active metabolite, oseltamivir carboxylate, in obese and nonobese healthy subjects. A single-dose, randomized, two-sequence crossover study was conducted in 12 obese and 12 n...

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Publisher copy:
10.1128/AAC.01786-13

Authors


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Journal:
Antimicrobial Agents and Chemotherapy
Volume:
58
Issue:
3
Pages:
1615-1621
Publication date:
2014-03-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Source identifiers:
459690
Language:
English
Pubs id:
pubs:459690
UUID:
uuid:cf9d6398-2159-4137-adf1-0d8683e6e6a3
Local pid:
pubs:459690
Deposit date:
2014-06-11

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