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Journal article

XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair.

Abstract:

XRCC1 is a scaffold protein that interacts with several DNA repair proteins and plays a critical role in DNA base excision repair (BER). XRCC1 protein is in a tight complex with DNA ligase IIIalpha (Lig III) and this complex is involved in the ligation step of both BER and repair of DNA single strand breaks. The majority of XRCC1 has previously been demonstrated to exist in a phosphorylated form and cells containing mutant XRCC1, that is unable to be phosphorylated, display a reduced rate of ...

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Publication status:
Published

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Journal:
DNA repair
Volume:
9
Issue:
7
Pages:
835-841
Publication date:
2010-07-01
DOI:
EISSN:
1568-7856
ISSN:
1568-7864
Source identifiers:
131017
Language:
English
Keywords:
Pubs id:
pubs:131017
UUID:
uuid:cf9c7582-f2bb-40e7-aa6b-c02f90efb772
Local pid:
pubs:131017
Deposit date:
2012-12-19

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