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Modulation of cardiac alternans by altered sarcoplasmic reticulum calcium release: A simulation study

Abstract:

Background

Cardiac alternans is an important precursor to arrhythmia, facilitating formation of conduction block, and re-entry. Diseased hearts were observed to be particularly vulnerable to alternans, mainly in heart failure or after myocardial infarction. Alternans is typically linked to oscillation of calcium cycling, particularly in the sarcoplasmic reticulum (SR). While the role of SR calcium reuptake in alternans is well established, the role of altered calcium release by r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Role:
Author
More from this funder
Name:
National Centre for the Replacement, Reduction and Refinement of Animals in Research
Funding agency for:
Rodriguez, B
Grant:
675451
More from this funder
Name:
European Commission
Funding agency for:
Rodriguez, B
Grant:
675451
More from this funder
Name:
British Heart Foundation
Funding agency for:
Rodriguez, B
Grant:
675451
More from this funder
Name:
Wellcome Trust
Funding agency for:
Tomek, J
Zhou, X
Rodriguez, B
Grant:
100246/Z/12/Z
100246/Z/12/Z
675451
More from this funder
Name:
Engineering and Physical Sciences Research Council
Funding agency for:
Tomek, J
Tomkova, M
Rodriguez, B
Grant:
100246/Z/12/Z
Ph.D. support
675451
Publisher:
Frontiers Media
Journal:
Frontiers in Physiology More from this journal
Volume:
9
Issue:
1
Pages:
1306
Publication date:
2018-09-19
Acceptance date:
2018-08-29
DOI:
EISSN:
1664-042X
Keywords:
Pubs id:
pubs:922468
UUID:
uuid:cf99bc12-18a1-4482-8478-fadd78ff0446
Local pid:
pubs:922468
Deposit date:
2018-09-29

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