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Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia.

Abstract:

Although angiogenesis is a prerequisite for the growth of most human solid tumours, alternative mechanisms of vascularisation can be adopted. We have previously described a non-angiogenic growth pattern in liver metastases of colorectal adenocarcinomas (CRC) in which tumour cells replace hepatocytes at the tumour-liver interface, preserving the liver architecture and co-opting the sinusoidal blood vessels. The aim of this study was to determine whether this replacement pattern occurs during l...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6601727

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Journal:
British journal of cancer
Volume:
90
Issue:
7
Pages:
1429-1436
Publication date:
2004-04-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Source identifiers:
102743

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