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Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses

Abstract:

Antibody affnity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and selection. Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHC II) proteins. How GC B cells are able to rapidly and repeatedly transition between mutating their B cell receptor genes and then being selected shortly after is not known. We report that MHC II surface levels and degradation are dynami...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1084/jem.20151682

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Ersching, J More by this author
Victora, GD More by this author
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Funding agency for:
Bannard, OM
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Funding agency for:
Bannard, OM
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Funding agency for:
McGowan, SJ
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Publication date:
2016-04-05
DOI:
ISSN:
1540-9538
URN:
uuid:cf93eca7-9cb6-4812-b3b4-a10585bca64f
Source identifiers:
619123
Local pid:
pubs:619123

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