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Journal article

Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses

Abstract:

Antibody affnity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and selection. Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHC II) proteins. How GC B cells are able to rapidly and repeatedly transition between mutating their B cell receptor genes and then being selected shortly after is not known. We report that MHC II surface levels and degradation are dynami...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1084/jem.20151682

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Funding agency for:
Bannard, O
McGowan, S
Grant:
105654/Z/14/Z
More from this funder
Funding agency for:
Bannard, O
Grant:
105654/Z/14/Z
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Publication date:
2016-04-01
Acceptance date:
2016-04-04
DOI:
ISSN:
1540-9538
Source identifiers:
619123
Pubs id:
pubs:619123
UUID:
uuid:cf93eca7-9cb6-4812-b3b4-a10585bca64f
Local pid:
pubs:619123
Deposit date:
2016-05-02

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