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Journal article

Adaptive evolution in perinatal HIV-1.

Abstract:

The immune-viral dynamics of the transmission of HIV-1 from mother to child are poorly understood, despite 20 years of research. Here we review evidence that the maternal immune response against HIV-1 can select forms of the virus that evade immunity and when transmitted have negative consequences in the child. Moreover, recent studies indicate that when wild-type virus is transmitted, an early immune response in the child can lead to the selection of viral escape forms in the first few month...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Journal:
Best practice and research. Clinical obstetrics and gynaecology
Volume:
19
Issue:
2
Pages:
211-229
Publication date:
2005-04-05
DOI:
EISSN:
1532-1932
ISSN:
1521-6934
URN:
uuid:cf860941-ded4-4c7d-84d6-9403d14d1cf2
Source identifiers:
24167
Local pid:
pubs:24167

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