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RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain

Abstract:

Angiogenesis, the formation of new blood vessels by endothelial cells, is a finely tuned process relying on the balance between promoting and repressing signalling pathways. Among these, Notch signalling is critical in ensuring appropriate response of endothelial cells to pro-angiogenic stimuli. However, the downstream targets and pathways effected by Delta-like 4 (DLL4)/Notch signalling and their subsequent contribution to angiogenesis are not fully understood. We found that the Rho GTPase, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s10456-020-09726-w

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0002-6958-6279
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Publisher:
Springer
Journal:
Angiogenesis More from this journal
Volume:
23
Issue:
3
Pages:
493-513
Publication date:
2020-06-06
Acceptance date:
2020-04-27
DOI:
EISSN:
1573-7209
ISSN:
0969-6970
Pmid:
32506201
Language:
English
Keywords:
Pubs id:
1112806
Local pid:
pubs:1112806
Deposit date:
2020-08-20

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