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In vitro quantitative imaging assay for phagocytosis of dead neuroblastoma cells by iPSC-macrophages

Abstract:

Microglia orchestrate neuroimmune responses in several neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Microglia clear up dead and dying neurons through the process of efferocytosis, a specialized form of phagocytosis. The phagocytosis function can be disrupted by environmental or genetic risk factors that affect microglia. This paper presents a rapid and simple in vitro microscopy protocol for studying microglial efferocytosis in an induced pluripotent stem...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3791/62217

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Brasenose College
Role:
Author
ORCID:
0000-0002-2506-1198
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-0297-6675
Alzheimers Research UK More from this funder
Publisher:
MyJove Corporation Publisher's website
Journal:
Journal of Visualized Experiments Journal website
Volume:
2021
Issue:
168
Article number:
e62217
Publication date:
2021-02-14
DOI:
EISSN:
1940-087X
Pmid:
33645588

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