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Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.

Abstract:

Despite recent advances in the treatment of hepatitis C, the quest for pan-genotype, effective, and well-tolerated inhibitors continues. To facilitate these efforts, it is desirable to have in vitro replication systems for all major HCV genotypes. However, cell culture replication systems exist for only genotypes 1a, 1b, and 2a. In this study, we generated G418-selectable subgenomic replicons for prototype strains of genotypes 3a (S52) and 4a (ED43). Production of G418-resistant colonies by S...

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Publisher copy:
10.1128/aac.01256-12

Authors


Scheel, TK More by this author
Gottwein, JM More by this author
Marukian, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Antimicrobial agents and chemotherapy
Volume:
56
Issue:
10
Pages:
5365-5373
Publication date:
2012-10-29
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:cf801ebe-c6df-461d-8f08-d0c06b52d505
Source identifiers:
426215
Local pid:
pubs:426215

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