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In vitro cellular models of human hepatic fatty acid metabolism: differences between Huh7 and HepG2 cell lines in human and fetal bovine culturing serum.

Abstract:

Human primary hepatocytes are the gold standard for investigating lipid metabolism in nonalcoholic fatty liver disease (NAFLD); however, due to limitations including availability and donor variability, the hepatoma cell lines Huh7 and HepG2 are commonly used. Culturing these cell lines in human serum (HS) has been reported to improve functionality; however, direct comparison of fatty acid (FA) metabolism in response to culturing in HS is lacking. The aim of this study was to compare FA metabo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.14814/phy2.13532

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Pramfalk, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
ORCID:
0000-0002-2648-6526
Medical Research Council More from this funder
Publisher:
Wiley Publisher's website
Journal:
Physiological Reports Journal website
Volume:
5
Issue:
24
Pages:
e13532
Publication date:
2017-12-05
Acceptance date:
2017-10-29
DOI:
EISSN:
2051-817X
Pubs id:
pubs:743629
URN:
uri:cf7fcc46-9340-4dd6-8ced-a48141dc33e7
UUID:
uuid:cf7fcc46-9340-4dd6-8ced-a48141dc33e7
Local pid:
pubs:743629
Language:
English
Keywords:

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