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Spots and stripes: pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation.

Abstract:

A key issue in stem cell biology is the differentiation of homogeneous stem cells towards different fates which are also organized into desired configurations. Little is known about the mechanisms underlying the process of periodic patterning. Feather explants offer a fundamental and testable model in which multi-potential cells are organized into hexagonally arranged primordia and the spacing between primordia. Previous work explored roles of a Turing reaction-diffusion mechanism in establis...

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Publication status:
Published

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Publisher copy:
10.1016/j.ydbio.2009.07.036

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Widelitz, RB More by this author
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Journal:
Developmental biology
Volume:
334
Issue:
2
Pages:
369-382
Publication date:
2009-10-05
DOI:
EISSN:
1095-564X
ISSN:
0012-1606
URN:
uuid:cf75cdef-e0d2-4a85-b94c-4c3c6f36c897
Source identifiers:
24353
Local pid:
pubs:24353

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