Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.
Sickle cell disease is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. Sickle cell disease can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Stroke affects around 10% of children with sickle cell anaemia (HbSS). Chronic blood transfusions may reduce the risk of vaso-occlusion and stroke by diluting the proportion of sickled cells in the circul...
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- Peer review status:
- Peer reviewed
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- Cochrane Collaboration
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- Copyright © 2017 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd. This is the publisher's version of the article. It is also available online from Wiley at: 10.1002/14651858.CD003146.pub3
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