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Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.

Abstract:

Background
Sickle cell disease is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. Sickle cell disease can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Stroke affects around 10% of children with sickle cell anaemia (HbSS). Chronic blood transfusions may reduce the risk of vaso-occlusion and stroke by diluting the proportion of sickled cells in the circul...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/14651858.CD003146.pub3

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, CSM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, CSM
Publisher:
Cochrane Collaboration Publisher's website
Journal:
Cochrane Database of Systematic Reviews Journal website
Volume:
1
Pages:
CD003146
Publication date:
2017-01-17
Acceptance date:
2017-01-12
DOI:
ISSN:
1469-493X
Pubs id:
pubs:672406
URN:
uri:cf741cf3-8f2d-4ba1-986a-5f985c618126
UUID:
uuid:cf741cf3-8f2d-4ba1-986a-5f985c618126
Local pid:
pubs:672406
Language:
English
Keywords:

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