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The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.

Abstract:

Two stable analogues of enkephalin D-Ala2-Met5-enkephalinamide (DAMA) and D-Ala2,D-Leu5-enkephalin (DADLE) injected bilaterally into the ventral tegmental area (VTA) induced locomotion, characterized by bursts of morphine-like activity. The response of DADLE was blocked by systemic-alpha-flupenthixol (0.2 mg/kg) and naloxone (1 mg/kg). At higher doses of enkephalins in the VTA, stereotypy behaviour involving gnawing, became apparent. When injected bilaterally into the globus pallidus (GP), bo...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Brain research
Volume:
221
Issue:
2
Pages:
359-370
Publication date:
1981-09-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:cf7359d4-f436-48f0-888d-935c57a3e3a7
Source identifiers:
1727
Local pid:
pubs:1727

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