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Journal article

The costs of close contacts: visualizing the energy landscape of cell contacts at the nanoscale

Abstract:

Cell-cell contacts often underpin signaling between cells. For immunology, the binding of a T cell receptor to an antigen-presenting pMHC initiates downstream signaling and an immune response. Although this contact is mediated by proteins on both cells creating interfaces with gap sizes typically around 14 nm, many, often contradictory observations have been made regarding the influence of the contact on parameters such as the binding kinetics, spatial distribution, and diffusion of signaling...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2020.01.019

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Name:
Wellcome Trust
Grant:
098274/12/Z
207547/Z/17/Z
Publisher:
Elsevier
Journal:
Biophysical Journal More from this journal
Publication date:
2020-01-28
Acceptance date:
2020-01-16
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Pmid:
32075748
Language:
English
Keywords:
Pubs id:
1090172
Local pid:
pubs:1090172
Deposit date:
2020-03-08

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