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Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain

Abstract:

Objective: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system associated with pathogenic autoantibodies against the astrocyte water channel protein aquaporin-4 (AQP4). The presence of neutrophils is a characteristic feature in NMO lesions in humans. Neutrophils are not generally found in multiple sclerosis lesions. We evaluated the role of neutrophils in a mouse NMO model. Methods: NMO lesions were produced in mice by intracerebral injection of i...

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Publisher copy:
10.1002/ana.22686

Authors


Saadoun, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
MacDonald, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Annals of Neurology
Volume:
71
Issue:
3
Pages:
323-333
Publication date:
2012-03-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:cf6de7d4-229a-4f0e-bb0c-b2b6b67b4ef3
Source identifiers:
323350
Local pid:
pubs:323350
Language:
English

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