Journal article icon

Journal article

pH and proton sensor GPR65 determine susceptibility to atopic dermatitis

Abstract:

pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin remains unknown. In this study, we performed a phenome-wide association study and report that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduces GPR65 signaling, showed a significant association with atopic dermatitis, in addition to inflammatory bowel diseases and asthma, as previously reported. Consistent with this genetic association in humans, we show that deficiency of ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.4049/jimmunol.2001363

Authors


More by this author
Role:
Author
ORCID:
0000-0001-7070-620X
More by this author
Role:
Author
ORCID:
0000-0003-0544-7488
Publisher:
The American Association of Immunologists
Journal:
Journal of Immunology More from this journal
Volume:
207
Issue:
1
Pages:
101-109
Publication date:
2021-07-01
Acceptance date:
2021-04-15
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pmid:
34135065
Language:
English
Keywords:
Pubs id:
1327741
Local pid:
pubs:1327741
Deposit date:
2023-02-07

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP