Journal article icon

Journal article

Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome.

Abstract:

BACKGROUND AND AIMS: Activating beta-catenin mutations in exon 3 have been implicated in colorectal tumorigenesis. Although reports to the contrary exist, it has been suggested that beta-catenin mutations occur more often in microsatellite unstable (MSI+) colorectal carcinomas, including hereditary non-polyposis colorectal cancer (HNPCC), as a consequence of defective DNA mismatch repair. We have analysed 337 colorectal carcinomas and adenomas, from both sporadic cases and HNPCC families, to ...

Expand abstract

Actions


Access Document


Publisher copy:
10.1136/gut.2004.048132

Authors


Journal:
Gut More from this journal
Volume:
54
Issue:
2
Pages:
264-267
Publication date:
2005-02-01
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
Language:
English
Keywords:
Pubs id:
pubs:72231
UUID:
uuid:cf59dce0-3ee9-49be-830c-853f9a31bc07
Local pid:
pubs:72231
Source identifiers:
72231
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP