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TNFα - A pivotal role in rheumatoid arthritis?

Abstract:

This review seeks to describe data which support the concept that TNFα has a pivotal role in the pathogenesis of RA. There is now compelling evidence from in vitro studies and in animal models that this is the case. The in vivo studies suggest that the direct pathogenic effects of TNFα are amplified by its potential to act as a potent paracrine molecule by inducing other pro-inflammatory molecules such as IL-1, and GM-CSF. It has yet to be established whether similar paracine effects of TNF-α...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
British Journal of Rheumatology More from this journal
Volume:
31
Issue:
5
Pages:
293-298
Publication date:
1992-01-01
ISSN:
0263-7103
Language:
English
Keywords:
Pubs id:
pubs:481853
UUID:
uuid:cf539bce-79ee-44bd-8f80-329dca8b404e
Local pid:
pubs:481853
Source identifiers:
481853
Deposit date:
2014-08-30

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