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Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels.

Abstract:

The endocrine part of the pancreas plays a central role in blood-glucose regulation. It is well established that an elevation of glucose concentration reduces secretion of the hyperglycaemia-associated hormone glucagon from pancreatic alpha 2 cells. The mechanisms involved, however, remain unknown. Electrophysiological studies have demonstrated that alpha 2 cells generate Ca2+-dependent action potentials. The frequency of these action potentials, which increases under conditions that stimulat...

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Publication status:
Published

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Publisher copy:
10.1038/341233a0

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Nature More from this journal
Volume:
341
Issue:
6239
Pages:
233-236
Publication date:
1989-09-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Keywords:
Pubs id:
pubs:22314
UUID:
uuid:cf4e0699-1fd4-4e94-b6c2-a0c54321b706
Local pid:
pubs:22314
Source identifiers:
22314
Deposit date:
2012-12-19

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