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Journal article

Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes

Abstract:

The rapid global distribution of COVID-19 vaccines, with over a billion doses administered, has been unprecedented. However, in comparison to most identified clinical determinants, the implications of individual genetic factors on antibody responses post-COVID-19 vaccination for breakthrough outcomes remain elusive. Here, we conducted a population-based study including 357,806 vaccinated participants with high-resolution HLA genotyping data, and a subset of 175,000 with antibody serology test...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-024-48339-5

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Research group:
NIHR Biomedical Research Centre Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Research group:
NIHR Biomedical Research Centre Oxford
Role:
Author
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
15
Issue:
1
Article number:
4031
Publication date:
2024-05-13
Acceptance date:
2024-04-29
DOI:
EISSN:
2041-1723
Language:
English
Pubs id:
1994958
Local pid:
pubs:1994958
Deposit date:
2024-05-08

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