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A gene expression profiling approach assessing celecoxib in a randomized controlled trial in prostate cancer.

Abstract:

BACKGROUND: We performed a pilot study, looking at the COX-2 inhibitor celecoxib, on newly diagnosed prostate cancer patients in the neo-adjuvant setting using DNA microarray analysis. PATIENTS AND METHODS: This was a single-blinded, randomized controlled phase II presurgical (radical prostatectomy) 28-day trial of celecoxib versus no drug in patients with localized T1-2 N0 M0 prostate cancer. cDNA microarray analysis was carried out on prostate cancer biopsies taken from freshly obtained ra...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Macanas-Pirard, P More by this author
Henderson, A More by this author
Langley, SE More by this author
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Journal:
Cancer genomics and proteomics
Volume:
6
Issue:
2
Pages:
93-99
Publication date:
2009
EISSN:
1790-6245
ISSN:
1109-6535
URN:
uuid:cf37ed9a-da47-4811-819c-f9be1a3e660a
Source identifiers:
414579
Local pid:
pubs:414579

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