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Journal article

Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins.

Abstract:

cAMP regulates cellular functions primarily by activating PKA. The involvement of PKAs in various signaling pathways occurring simultaneously in different cellular compartments necessitates stringent spatial and temporal regulation. This specificity is largely achieved by binding of PKA to protein scaffolds, whereby a distinct group of proteins called A kinase anchoring proteins (AKAPs) play a dominant role. AKAPs are a diverse family of proteins that all bind via a small PKA binding domain t...

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Publication status:
Published

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Publisher copy:
10.1074/mcp.m800226-mcp200

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
Journal:
Molecular and cellular proteomics : MCP More from this journal
Volume:
8
Issue:
5
Pages:
1016-1028
Publication date:
2009-05-01
DOI:
EISSN:
1535-9484
ISSN:
1535-9476
Language:
English
Keywords:
Pubs id:
pubs:384595
UUID:
uuid:cf37889d-479a-4666-b4c9-0735f212df5f
Local pid:
pubs:384595
Source identifiers:
384595
Deposit date:
2013-11-16

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