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Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies

Abstract:

Choosing the appropriate neuroimaging phenotype is critical to successfully identify genes that influence brain structure or function. While neuroimaging methods provide numerous potential phenotypes, their role for imaging genetics studies is unclear. Here we examine the relationship between brain volume, grey matter volume, cortical thickness and surface area, from a genetic standpoint. Four hundred and eighty-six individuals from randomly ascertained extended pedigrees with high-quality T1...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Kochunov, P More by this author
Blangero, J More by this author
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Publisher:
Elsevier Inc. Publisher's website
Journal:
NeuroImage Journal website
Volume:
53
Issue:
3
Pages:
1135-1146
Publication date:
2010-11-15
DOI:
ISSN:
1053-8119
URN:
uuid:cf30dcaa-fc46-459f-b722-24983da7747b
Source identifiers:
445989
Local pid:
pubs:445989

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