Next generation sequencing in disease-relevant tissues

Thesis

Studies of RNA and the transcriptome are of great importance in providing functional information and unravelling the genetic mechanisms that underlie complex disorders and diseases. With the vast majority of complex disease-associated variants falling outside protein-coding regions of the genome, it is likely that variations in gene expression regulation will be essential to understanding disease aetiology. Information on RNA quantity and splicing isoforms is therefore likely to be crucial...

Expand abstract

Authors: Clifford, H

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: NGS; RNA-Seq
• Subjects: Genomics; Computational biology; Bioinformatics; Genetics