Journal article
PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia
- Abstract:
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Acquired uniparental disomy (aUPD, also known as copy-neutral loss of heterozygosity) is a common feature of cancer cells and characterized by extended tracts of somatically-acquired homozygosity without any concurrent loss or gain of genetic material. The presumed genetic targets of many regions of aUPD remain unknown. Here we describe the association of chromosome 22 aUPD with mutations that delete the C-terminus of PRR14L in patients with chronic myelomonocytic leukemia (CMML), related mye...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 559.2KB)
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(Accepted manuscript, docx, 5.9MB)
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- Publisher copy:
- 10.1038/s41375-018-0340-5
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Leukemia Journal website
- Volume:
- 33
- Pages:
- 1184–1194
- Publication date:
- 2018-12-20
- Acceptance date:
- 2018-10-03
- DOI:
- ISSN:
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1476-5551
- Source identifiers:
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954617
Item Description
- Language:
- English
- Pubs id:
-
pubs:954617
- UUID:
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uuid:cf26a167-29f1-4352-bce3-dd95e5242894
- Local pid:
- pubs:954617
- Deposit date:
- 2018-12-24
Terms of use
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2018
- Notes:
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Copyright © 2018 Springer Nature Limited.
This is the accepted manuscript version of the article. The final version is available online from Springer at: https://doi.org/10.1038/s41375-018-0340-5
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