Journal article
PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia
- Abstract:
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Acquired uniparental disomy (aUPD, also known as copy-neutral loss of heterozygosity) is a common feature of cancer cells and characterized by extended tracts of somatically-acquired homozygosity without any concurrent loss or gain of genetic material. The presumed genetic targets of many regions of aUPD remain unknown. Here we describe the association of chromosome 22 aUPD with mutations that delete the C-terminus of PRR14L in patients with chronic myelomonocytic leukemia (CMML), related mye...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
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(docx, 5.9MB)
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(pdf, 559.2KB)
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- Publisher copy:
- 10.1038/s41375-018-0340-5
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Authors
Funding
+ Bloodwise
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Grant:
Specialist Programme Grants 13002 to NCPC, AC and WT
13042 to JB and AP
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Leukemia Journal website
- Volume:
- 33
- Pages:
- 1184–1194
- Publication date:
- 2018-12-20
- Acceptance date:
- 2018-10-03
- DOI:
- ISSN:
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1476-5551
- Pubs id:
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pubs:954617
- URN:
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uri:cf26a167-29f1-4352-bce3-dd95e5242894
- UUID:
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uuid:cf26a167-29f1-4352-bce3-dd95e5242894
- Local pid:
- pubs:954617
Item Description
- Language:
- English
Terms of use
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 Springer Nature Limited.
This is the accepted manuscript version of the article. The final version is available online from Springer at: https://doi.org/10.1038/s41375-018-0340-5
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