Journal article icon

Journal article

CD2 sets quantitative thresholds in T cell activation.

Abstract:

It has been proposed that CD2, which is highly expressed on T cells, serves to enhance T cell-antigen presenting cell (APC) adhesion and costimulate T cell activation. Here we analyzed the role of CD2 using CD2-deficient mice crossed with transgenic mice expressing a T cell receptor specific for lymphocytic choriomeningitis virus (LCMV)-derived peptide p33. We found that absence of CD2 on T cells shifted the p33-specific dose-response curve in vitro by a factor of 3-10. In comparison, stimula...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1084/jem.190.10.1383
Journal:
Journal of experimental medicine More from this journal
Volume:
190
Issue:
10
Pages:
1383-1392
Publication date:
1999-11-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
pubs:469223
UUID:
uuid:cf1dce1b-06dd-430d-9667-11ac2b63a11c
Local pid:
pubs:469223
Source identifiers:
469223
Deposit date:
2014-06-17

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP