CD2 sets quantitative thresholds in T cell activation.

Journal article

It has been proposed that CD2, which is highly expressed on T cells, serves to enhance T cell-antigen presenting cell (APC) adhesion and costimulate T cell activation. Here we analyzed the role of CD2 using CD2-deficient mice crossed with transgenic mice expressing a T cell receptor specific for lymphocytic choriomeningitis virus (LCMV)-derived peptide p33. We found that absence of CD2 on T cells shifted the p33-specific dose-response curve in vitro by a factor of 3-10. In comparison, stimula...

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Authors: Bachmann, M; Barner, M; Kopf, M

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 190
• Issue: 10
• Pages: 1383-1392
• Publication date: 1999-11-01
• DOI: 10.1084/jem.190.10.1383
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Calcium; Animals; Mice; Intercellular Adhesion Molecule-1; Antigens, CD; Mice, Inbred C57BL; Antigens, CD2; T-Lymphocytes; Receptors, Antigen, T-Cell; Lymphocyte Function-Associated Antigen-1; Lymphocyte Activation; Mice, Transgenic