Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway.

Journal article

OBJECTIVES: To establish if changes in Th1/Th17 cell populations previously reported in experimental arthritis occur in patients with rheumatoid arthritis (RA) treated with anti-tumour necrosis factor α (TNFα) agents, and whether the therapeutic response to anti-TNFα is compromised in patients and mice because of elevated Th17/IL-17 levels. Finally, to assess the efficacy of combined blockade of anti-TNFα and anti-IL-17 in experimental arthritis. METHODS: A longitudinal study of two independe...

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Authors: Alzabin, S; Abraham, S; Taher, T; Palfreeman, A; Hull, D

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 71
• Issue: 10
• Pages: 1741-1748
• Publication date: 2012-10-01
• DOI: 10.1136/annrheumdis-2011-201024
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Animals; Flow Cytometry; Antirheumatic Agents; Mice; Interleukin-17; Humans; Real-Time Polymerase Chain Reaction; Female; Male; Tumor Necrosis Factor-alpha; Th17 Cells; Enzyme-Linked Immunosorbent Assay; Longitudinal Studies; Arthritis, Rheumatoid; Arthritis, Experimental; Middle Aged; Drug Resistance