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Threonine Phosphorylation of IκBζ Mediates Inhibition of Selective Proinflammatory Target Genes

Abstract:

Transcription factors of the NF-κB family play a crucial role for immune responses by activating the expression of chemokines, cytokines, and antimicrobial peptides involved in pathogen clearance. IκBζ, an atypical nuclear IκB protein and selective coactivator of particular NF-κB target genes, has recently been identified as an essential regulator for skin immunity. This study discovered that IκBζ is strongly induced in keratinocytes that sense the fungal glucan zymosan A. Additionally, IκBζ ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jid.2019.12.036

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Publisher:
Elsevier
Journal:
Journal of Investigative Dermatology More from this journal
Volume:
140
Issue:
9
Pages:
1805-1814.E6
Publication date:
2020-02-06
Acceptance date:
2019-12-23
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
Pmid:
32035922
Language:
English
Keywords:
Pubs id:
1087368
Local pid:
pubs:1087368
Deposit date:
2020-03-17

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