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Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation

Abstract:

Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthases (NOS). Oral BH4 supplementation preserves cardiac function in animal models of cardiac disease; however, the mechanisms underlying these findings are not completely understood.To study the effect of myocardial transgenic overexpression of the rate-limiting enzyme in BH4 biosynthesis, GTP cyclohydrolase 1 (GCH1), on NOS activity, myocardial function, and Ca2+ handling.GCH1overexpression significantly increased the bio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Expand authors...
Medical Research Council More from this funder
British Heart Foundation More from this funder
Garfield Weston Trust More from this funder
Fondation Leducq Network of Excellence More from this funder
Publisher:
American Heart Association Publisher's website
Journal:
Circulation Research Journal website
Volume:
111
Issue:
6
Pages:
718-727
Publication date:
2012-01-01
Acceptance date:
2012-07-10
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Source identifiers:
342326
Language:
English
Keywords:
Pubs id:
pubs:342326
UUID:
uuid:cf0ffc80-b239-4251-ae9e-9eb086bc7c4b
Local pid:
pubs:342326
Deposit date:
2012-12-19

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