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Pathways of IL-1β secretion by macrophages infected with clinical Mycobacterium tuberculosis strains.

Abstract:

The pro-inflammatory cytokine IL-1β is a key mediator of inflammation and plays an important role in the host resistance to Mycobacterium tuberculosis infections. To date, most studies have examined the mechanisms of IL-1β secretion using laboratory strains of M. tuberculosis and the findings may not be widely applicable to contemporary clinical strains. Here, we investigated the primary pathways of IL-1β secretion in macrophages infected with a panel of 17 clinical M. tuberculosis isolates, ...

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Publisher copy:
10.1016/j.tube.2013.05.002

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Tuberculosis (Edinburgh, Scotland) More from this journal
Volume:
93
Issue:
5
Pages:
538-547
Publication date:
2013-09-01
DOI:
EISSN:
1873-281X
ISSN:
1472-9792
Language:
English
Keywords:
Pubs id:
pubs:435213
UUID:
uuid:cf0a9bfa-8968-4933-92be-76bcf83b2783
Local pid:
pubs:435213
Source identifiers:
435213
Deposit date:
2014-02-14

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