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LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing.

Abstract:

Fas and TNF-R1 are cysteine-rich cell surface receptors related to the low-affinity nerve growth factor receptor family. Engagement of these receptors by their respective ligands, FasL and tumor necrosis factor, leads to apoptosis that is signaled through a conserved intracellular portion of the receptor termed the "death domain." We have cloned a new member of this family, lymphocyte-associated receptor of death (LARD), which leads to spontaneous apoptosis when expressed in 293T cells. The e...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.94.9.4615

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
94
Issue:
9
Pages:
4615-4619
Publication date:
1997-04-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424

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