- Abstract:
-
Fms interacting protein (FMIP) is a substrate for Fms tyrosine kinase, and a nuclear/cytoplasm shuttling protein with a leucine zipper. As the phosphorylation of FMIP is observed in insulin-stimulated preadipocytes, we examined the role of FMIP in adipocyte differentiation, using the mesenchymal multipotent stem cells, C2C12 cells, that can differentiate into adipocytes, muscle cells and osteoblasts. Ectopic expression of FMIP in C2C12 impairs the adipocyte differentiation induced by treatmen...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/sj.onc.1209853
-
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- Journal:
- Oncogene
- Volume:
- 26
- Issue:
- 7
- Pages:
- 1020-1027
- Publication date:
- 2007-02-05
- DOI:
- EISSN:
-
1476-5594
- ISSN:
-
0950-9232
- URN:
-
uuid:ceff6cb1-f650-4182-beb0-1e7e46d3cc30
- Source identifiers:
-
246499
- Local pid:
- pubs:246499
- Copyright date:
- 2007
Journal article
FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.
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