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FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.

Abstract:

Fms interacting protein (FMIP) is a substrate for Fms tyrosine kinase, and a nuclear/cytoplasm shuttling protein with a leucine zipper. As the phosphorylation of FMIP is observed in insulin-stimulated preadipocytes, we examined the role of FMIP in adipocyte differentiation, using the mesenchymal multipotent stem cells, C2C12 cells, that can differentiate into adipocytes, muscle cells and osteoblasts. Ectopic expression of FMIP in C2C12 impairs the adipocyte differentiation induced by treatmen...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1209853

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Journal:
Oncogene
Volume:
26
Issue:
7
Pages:
1020-1027
Publication date:
2007-02-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:ceff6cb1-f650-4182-beb0-1e7e46d3cc30
Source identifiers:
246499
Local pid:
pubs:246499

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