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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

Abstract:

BACKGROUND: Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimalarials is extremely limited. Addressing the urgent need for the development of new antimalarials, a chemical class of potent antimalarial compounds with a novel mode of action was recently identified. Herein, the preclinical characterization of o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1002138

Authors


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Actelion Pharmaceuticals Ltd More from this funder
Medicines for Malaria Venture More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Med Journal website
Volume:
13
Issue:
10
Chapter number:
e1002138
Publication date:
2016-10-04
Acceptance date:
2016-08-24
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:653604
URN:
uri:cefd75de-e423-41b9-acc8-5bc1ebc0cf7a
UUID:
uuid:cefd75de-e423-41b9-acc8-5bc1ebc0cf7a
Local pid:
pubs:653604
Paper number:
10

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