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Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.

Abstract:

The identification of susceptibility genes for human disease is a major goal of current biomedical research. Both sequence and structural variation have emerged as major genetic sources of phenotypic variability and growing evidence points to copy number variation as a particularly important source of susceptibility for disease. Here we propose and validate a strategy to identify genes in which changes in dosage alter susceptibility to disease-relevant phenotypes in the mouse. Our approach re...

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Publisher copy:
10.1002/emmm.201000112

Authors


Journal:
EMBO molecular medicine More from this journal
Volume:
3
Issue:
1
Pages:
50-66
Publication date:
2011-01-01
DOI:
EISSN:
1757-4684
ISSN:
1757-4676
Language:
English
Keywords:
Pubs id:
pubs:324080
UUID:
uuid:cef62abe-d8f6-4658-b7ba-af43d8f1afba
Local pid:
pubs:324080
Source identifiers:
324080
Deposit date:
2012-12-19

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