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Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger.

Abstract:

The neuropeptides orexins/hypocretins are essential for normal wakefulness and energy balance, and disruption of their function causes narcolepsy and obesity. Although much is known of the role of orexins in sleep/wake behavior, it remains unclear how they stimulate feeding and metabolism. One of the main targets of orexinergic neurons is the arcuate nucleus (ARC) of the hypothalamus, which plays a key role in feeding and energy homeostasis. By combining patch-clamp and RT-multiplex PCR analy...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience More from this journal
Volume:
23
Issue:
12
Pages:
4951-4957
Publication date:
2003-06-01
EISSN:
1529-2401
ISSN:
0270-6474

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