Journal article icon

Journal article

A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.

Abstract:

OBJECTIVES: The aim of this study was to assess if genetic variation in the PACE4 (paired amino acid converting enzyme 4) gene Pcsk6 influences the risk for symptomatic knee osteoarthritis (OA). METHODS: Ten PCSK6 single nucleotide polymorphisms were tested for association in a discovery cohort of radiographic knee OA (n=156 asymptomatic and 600 symptomatic cases). Meta-analysis of the minor allele at rs900414 was performed in three additional independent cohorts (total n=674 asymptomatic an...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Annals of the rheumatic diseases
Volume:
71
Issue:
6
Pages:
1042-1048
Publication date:
2012-06-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:ceed5978-df31-481f-bce2-d21cdf11497a
Source identifiers:
341513
Local pid:
pubs:341513

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP