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Journal article

Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.

Abstract:

The human breast cancer susceptibility gene BRCA2 is required for the regulation of RAD51-mediated homologous recombinational repair. BRCA2 interacts with RAD51 monomers, as well as nucleoprotein filaments, primarily though the conserved BRC motifs. The unrelated C-terminal region of BRCA2 also interacts with RAD51. Here we show that the BRCA2 C terminus interacts directly with RAD51 filaments, but not monomers, by binding an interface created by two adjacent RAD51 protomers. These interactio...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb1245

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Nature structural and molecular biology More from this journal
Volume:
14
Issue:
6
Pages:
468-474
Publication date:
2007-06-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Language:
English
Keywords:
Pubs id:
pubs:55337
UUID:
uuid:ceeb966b-622b-4e0d-a9e0-582581de068b
Local pid:
pubs:55337
Source identifiers:
55337
Deposit date:
2012-12-19

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