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Journal article

Molecular targets for altering radiosensitivity: lessons from Ras as a pre-clinical and clinical model.

Abstract:

Ras activation has been correlated with malignant and metastatic cancer phenotypes and poor prognosis for cancer patients. In the preclinical setting, Ras activation by mutation or EGFR amplification results in increased clonogenic cell survival and decreased tumor growth delay following irradiation. Activation of the Ras pathway has also been associated with increased risk of local failure and decreased overall survival in patients receiving radiotherapy. Prenyltransferase inhibitors target ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Critical reviews in oncology/hematology More from this journal
Volume:
55
Issue:
2
Pages:
103-116
Publication date:
2005-08-01
DOI:
EISSN:
1879-0461
ISSN:
1040-8428
Language:
English
Keywords:
Pubs id:
pubs:118208
UUID:
uuid:ceeadf27-e6ac-4b9c-b3d9-65d8e7abf99d
Local pid:
pubs:118208
Source identifiers:
118208
Deposit date:
2012-12-19

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