Journal article icon

Journal article

Distinctive patterns of transcription and RNA processing for human lincRNAs

Abstract:

Numerous long intervening noncoding RNAs (lincRNAs) are generated from the mammalian genome by RNA polymerase II (Pol II) transcription. Although multiple functions have been ascribed to lincRNAs, their synthesis and turnover remain poorly characterized. Here, we define systematic differences in transcription and RNA processing between protein-coding and lincRNA genes in human HeLa cells. This is based on a range of nascent transcriptomic approaches applied to different nuclear fractions, inc...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.molcel.2016.11.029

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0003-1333-0191
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-2481-9729
Expand authors...
Portuguese Foundation for Science and Technology More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Molecular Cell Journal website
Volume:
65
Issue:
1
Pages:
25-38
Publication date:
2016-12-22
Acceptance date:
2016-11-17
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pmid:
28017589
Source identifiers:
667822

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP