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Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.

Abstract:

FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl beta-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor that regulates the mammalian hypoxic response. Only one other asparaginyl beta-hydroxylase, which catalyses hydroxylation of both aspartyl and asparaginyl residues in EGF (epidermal growth factor)-like domains, has been characterized. In the lig...

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Publication status:
Published

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Publisher copy:
10.1042/BST0320943

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Biochemical Society transactions
Volume:
32
Issue:
Pt 6
Pages:
943-945
Publication date:
2004-12-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:cedf0bd7-764c-41b9-a5fa-7a3fa88e3902
Source identifiers:
32888
Local pid:
pubs:32888

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