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Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

Abstract:

Clavulanic acid and avibactam are clinically deployed serine β-lactamase inhibitors, important as a defence against antibacterial resistance. Bicyclic boronates are recently discovered inhibitors of serine and some metallo β-lactamases. Here, we show that avibactam and a bicyclic boronate inhibit L2 (serine β-lactamase) but not L1 (metallo β-lactamase) from the extensively drug resistant human pathogen Stenotrophomonas maltophilia. X-ray crystallography revealed that both inhibitors bind L2 b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/mmi.13831

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
ORCID:
0000-0002-0137-3226
More from this funder
Name:
National Institutes of Health
Grant:
R01AI100560
More from this funder
Name:
Medical Research Council
Grant:
EP/M027546/1
More from this funder
Name:
Canadian Institute for Health Research
Publisher:
Wiley
Journal:
Molecular Microbiology More from this journal
Volume:
106
Issue:
3
Pages:
492-504
Publication date:
2017-09-06
Acceptance date:
2017-09-05
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
Pmid:
28876489
Language:
English
Keywords:
Pubs id:
pubs:725830
UUID:
uuid:cedb5b7a-0c23-495e-94e2-8bf1d9ebf628
Local pid:
pubs:725830
Source identifiers:
725830
Deposit date:
2018-04-24

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