Journal article
Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates
- Abstract:
-
Clavulanic acid and avibactam are clinically deployed serine β-lactamase inhibitors, important as a defence against antibacterial resistance. Bicyclic boronates are recently discovered inhibitors of serine and some metallo β-lactamases. Here, we show that avibactam and a bicyclic boronate inhibit L2 (serine β-lactamase) but not L1 (metallo β-lactamase) from the extensively drug resistant human pathogen Stenotrophomonas maltophilia. X-ray crystallography revealed that both inhibitors bind L2 b...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Canadian Institute for Health Research
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Molecular Microbiology Journal website
- Volume:
- 106
- Issue:
- 3
- Pages:
- 492-504
- Publication date:
- 2017-09-06
- Acceptance date:
- 2017-09-05
- DOI:
- EISSN:
-
1365-2958
- ISSN:
-
0950-382X
- Pmid:
-
28876489
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:725830
- UUID:
-
uuid:cedb5b7a-0c23-495e-94e2-8bf1d9ebf628
- Local pid:
- pubs:725830
- Source identifiers:
-
725830
- Deposit date:
- 2018-04-24
Terms of use
- Copyright holder:
- John Wiley and Sons Ltd
- Copyright date:
- 2017
- Notes:
- © 2017 John Wiley and Sons Ltd. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1111/mmi.13831
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