- Abstract:
-
The opiate control of vasopressin secretion in man was investigated with a long-acting analogue of met-enkephalin, DAMME (FK33-824, Sandoz). Infusion of 1 mg DAMME into water-deprived volunteers produced a diuresis which was attenuated by naloxone; there was no change in water excretion when subjects were hydrated. Plasma-immunoreactive-vasopressin failed to rise after DAMME administration, despite osmotic stimulation with hypertonic saline infusion. Opiates appear to be involved in mechanism...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0140-6736(80)92542-8
-
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- Journal:
- Lancet
- Volume:
- 2
- Issue:
- 8204
- Pages:
- 1108-1110
- Publication date:
- 1980-11-05
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- URN:
-
uuid:ced8295f-c04d-40f0-898f-1a8ad2104456
- Source identifiers:
-
138611
- Local pid:
- pubs:138611
- Copyright date:
- 1980
Journal article
Inhibition of vasopressin release in man by an opiate peptide.
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