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Inhibition of vasopressin release in man by an opiate peptide.

Abstract:

The opiate control of vasopressin secretion in man was investigated with a long-acting analogue of met-enkephalin, DAMME (FK33-824, Sandoz). Infusion of 1 mg DAMME into water-deprived volunteers produced a diuresis which was attenuated by naloxone; there was no change in water excretion when subjects were hydrated. Plasma-immunoreactive-vasopressin failed to rise after DAMME administration, despite osmotic stimulation with hypertonic saline infusion. Opiates appear to be involved in mechanism...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Besser, GM More by this author
Milles, JJ More by this author
Baylis, PH More by this author
Journal:
Lancet
Volume:
2
Issue:
8204
Pages:
1108-1110
Publication date:
1980-11-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:ced8295f-c04d-40f0-898f-1a8ad2104456
Source identifiers:
138611
Local pid:
pubs:138611

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