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Journal article

Genome-scale identification of cellular pathways required for cell surface recognition

Abstract:

Interactions mediated by cell surface receptors initiate important instructive signaling cues but can be difficult to detect in biochemical assays because they are often highly transient and membrane-embedded receptors are difficult to solubilize in their native conformation. Here, we address these biochemical challenges by using a genome-scale, cell-based genetic screening approach using CRISPR gene knockout technology to identify cellular pathways required for specific cell surface recognit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/gr.231183.117

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
Publisher:
Cold Spring Harbor Laboratory Press
Journal:
Genome Research More from this journal
Volume:
28
Issue:
9
Pages:
1372-1382
Publication date:
2018-06-18
Acceptance date:
2018-06-15
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Language:
English
Keywords:
Pubs id:
1125058
Local pid:
pubs:1125058
Deposit date:
2021-04-30

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