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A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy.

Abstract:

PURPOSE: Hans and coworkers previously developed an immunohistochemical algorithm with approximately 80% concordance with the gene expression profiling (GEP) classification of diffuse large B-cell lymphoma (DLBCL) into the germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subtypes. Since then, new antibodies specific to germinal center B-cells have been developed, which might improve the performance of an immunostain algorithm. EXPERIMENTAL DESIGN: We studied 84 cases of cycl...

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Publication status:
Published

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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research More from this journal
Volume:
15
Issue:
17
Pages:
5494-5502
Publication date:
2009-09-01
DOI:
EISSN:
1557-3265
ISSN:
1078-0432

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