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Activation of the opioidergic descending pain control system underlies placebo analgesia.

Abstract:

Placebo analgesia involves the endogenous opioid system, as administration of the opioid antagonist naloxone decreases placebo analgesia. To investigate the opioidergic mechanisms that underlie placebo analgesia, we combined naloxone administration with functional magnetic resonance imaging. Naloxone reduced both behavioral and neural placebo effects as well as placebo-induced responses in pain-modulatory cortical structures, such as the rostral anterior cingulate cortex (rACC). In a brainste...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Schoell, ED More by this author
Yacubian, J More by this author
Klinger, R More by this author
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Journal:
Neuron
Volume:
63
Issue:
4
Pages:
533-543
Publication date:
2009-08-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:cecf7c8e-7065-40c2-932e-33d446c8b875
Source identifiers:
241588
Local pid:
pubs:241588

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