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The membrane characteristics of Plasmodium falciparum-infected and -uninfected heterozygous alpha(0)thalassaemic erythrocytes.

Abstract:

The alpha thalassaemias are the commonest known human genetic disorders. Although they have almost certainly risen to their current frequencies through natural selection by malaria, the precise mechanism of malaria protection remains unknown. We have investigated the characteristics of red blood cells (RBCs) from individuals heterozygous for alpha(0)thalassaemia (-/alphaalpha) from a range of perspectives. On the basis of the hypothesis that defects in membrane transport could be relevant to ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Weatherall, DJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Journal:
British journal of haematology
Volume:
118
Issue:
2
Pages:
663-670
Publication date:
2002-08-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:cecf01c3-fe93-4442-b35c-84ad80d119e9
Source identifiers:
13463
Local pid:
pubs:13463

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