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Journal article

Neuronal loss and brain atrophy in mice lacking cathepsins B and L.

Abstract:

Cathepsins B and L are widely expressed cysteine proteases implicated in both intracellular proteolysis and extracellular matrix remodeling. However, specific roles remain to be validated in vivo. Here we show that combined deficiency of cathepsins B and L in mice is lethal during the second to fourth week of life. Cathepsin B(-/-)/L(-/-) mice reveal a degree of brain atrophy not previously seen in mice. This is because of massive apoptosis of select neurons in the cerebral cortex and the cer...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.112632299

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
99
Issue:
12
Pages:
7883-7888
Publication date:
2002-06-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:21614
UUID:
uuid:cec38001-6a19-45cb-84af-6578dd16b7db
Local pid:
pubs:21614
Source identifiers:
21614
Deposit date:
2012-12-19

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