- Abstract:
-
PURPOSE: Laboratory and case-control studies suggest a pivotal role for the cyclooxygenase-2 (COX-2) pathway in colorectal carcinogenesis. The purpose of this study was to test whether the COX-2 inhibitor rofecoxib could reduce recurrence and improve survival when administered in the adjuvant setting of colorectal cancer (CRC). PATIENTS AND METHODS: Patients who had undergone potentially curative surgery and completion of adjuvant therapy for stage II and III CRC were randomly assigned to re...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1200/jco.2010.29.6244
-
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- Journal:
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Volume:
- 28
- Issue:
- 30
- Pages:
- 4575-4580
- Publication date:
- 2010-10-05
- DOI:
- EISSN:
-
1527-7755
- ISSN:
-
0732-183X
- URN:
-
uuid:cec2e818-1f01-4cba-8915-e1b2610dfb2f
- Source identifiers:
-
257431
- Local pid:
- pubs:257431
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Phase III randomized trial assessing rofecoxib in the adjuvant setting of colorectal cancer: final results of the VICTOR trial.
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